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KMID : 0615720020190020105
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Jouranl of Korean Acupuncture and Moxibustion society
2002 Volume.19 No. 2 p.105 ~ p.113
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Protective Effect of Diallyl disulfide(DADS) from Garlic Extract on Noise Induced Hearing Loss in the Guinea pigs
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Abstract
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Objective : The purpose of this study is to investigate the protective effect of DADS on the noise induced hearing loss
Methods : Twenty healthy guinea pigs (DADS pretreated group and control) were exposed to 100dB a collected environmental noise for 9 hours. An auditory evoked brainstem response (ABR) threshold was measured before and after a noise exposure. For morphological study, cochlea was studied by scanning electron microscope (SEM).
Results : The DADS pretreated group showed statistically significant less changes in ABR threshold and SEM findings compared the control group.
Conclusion : From these results suggest that the DADS from garlic may have a protective effect in noise induced hearing loss.
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